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Las células de soporte coclear de los mamíferos pueden dividirse y transdiferenciarse en células ciliadas
Patricia M White1, Angelika Doetzlhofer, Yun Shain Lee
1Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W. Third Street, Los Angeles, California 90057, USA.
Nature
|June 23, 2006
Resumen
Las células ciliadas del oído interno de los mamíferos no se regeneran. Sin embargo, las células de soporte postnatal pueden dividirse y convertirse en nuevas células ciliadas, ofreciendo un potencial terapéutico para la pérdida auditiva.
Área de la Ciencia:
- Oto-neurología.
- Biología celular Biología celular.
- La Medicina Regenerativa es una Medicina Regenerativa.
Sus antecedentes:
- Las células ciliadas sensoriales en el órgano del oído interno de los mamíferos de Corti no se regeneran después de un daño.
- A diferencia de las aves, los mamíferos carecen de regeneración de células ciliadas, lo que plantea preguntas sobre el apoyo a la plasticidad celular.
Objetivo del estudio:
- Investigar el potencial regenerativo de las células de apoyo cocleares de mamíferos posnatales.
- Para determinar si las células de soporte pueden dividirse y diferenciarse en células ciliadas.
Principales métodos:
- Purificación de las células de soporte postmitóticas de las cócleas de ratón postnatal.
- Cultivo de estas células para evaluar sus capacidades de proliferación y diferenciación.
- Analizando los cambios dependientes de la edad en el apoyo a la proliferación celular, centrándose en la regulación de la p27 (Kip1).
Principales resultados:
- Las células de soporte de mamíferos postnatales conservan la capacidad de dividirse y transdiferenciarse en células ciliadas en cultivo.
- La disminución dependiente de la edad en el apoyo a la proliferación celular se debe en parte a la alteración de la regulación a la baja de p27 (Kip1) (Cdkn1b).
Conclusiones:
- Las células de apoyo de mamíferos posnatales poseen un potencial regenerativo inherente.
- Las estrategias terapéuticas dirigidas a apoyar la proliferación celular pueden restaurar las células ciliadas y tratar la sordera.
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