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Nuclear Stability03:18

Nuclear Stability

Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together in the...
Nuclear Power02:36

Nuclear Power

Controlled nuclear fission reactions are used to generate electricity. Any nuclear reactor that produces power via the fission of uranium or plutonium by bombardment with neutrons has six components: nuclear fuel consisting of fissionable material, a nuclear moderator, a neutron source, control rods, reactor coolant, and a shield and containment system.
Nuclear Fuels
Nuclear fuel consists of a fissile isotope, such as uranium-235, which must be present in sufficient quantity to provide a...
Nuclear Fusion02:45

Nuclear Fusion

The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
Nuclear Transmutation03:20

Nuclear Transmutation

Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed protons being...
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.

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Updated: Jul 6, 2026

Preparation and Evaluation of Hybrid Composites of Chemical Fuel and Multi-walled Carbon Nanotubes in the Study of Thermopower Waves
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Published on: April 10, 2015

La reprogramación nuclear y la pluripotencia.

Konrad Hochedlinger1, Rudolf Jaenisch

  • 1Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.

Nature
|July 1, 2006
PubMed
Resumen
Este resumen es generado por máquina.

La clonación de mamíferos muestra que los núcleos celulares adultos pueden ser reprogramados a un estado embrionario, lo que permite el desarrollo de nuevos organismos. Esto abre las puertas a la medicina regenerativa y a las células madre específicas del paciente.

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Área de la Ciencia:

  • Biología de la reproducción Biología reproductiva.
  • Biología del desarrollo Biología del desarrollo.
  • La ciencia de las células madre.

Sus antecedentes:

  • La clonación de mamíferos a partir de células diferenciadas desafía la visión de un desarrollo irreversible.
  • La capacidad del ovocito para reprogramar núcleos adultos en un estado embrionario es clave.

Objetivo del estudio:

  • Para resaltar el potencial de la transferencia nuclear en la medicina regenerativa.
  • Explorar futuras alternativas a la reprogramación nuclear dependiente de los ovocitos.

Principales métodos:

  • Transferencia nuclear de células donantes diferenciadas en ovocitos enucleados.
  • Observación del desarrollo embrionario dirigido por el núcleo reprogramado.

Principales resultados:

  • La clonación exitosa de mamíferos a partir de células diferenciadas.
  • Demostración de la reprogramación nuclear mediada por ovocitos hasta el estado embrionario.
  • Potencial para la obtención de células madre embrionarias específicas del paciente.

Conclusiones:

  • La clonación de mamíferos refuta el dogma del desarrollo irreversible.
  • La tecnología de transferencia nuclear es prometedora para la medicina regenerativa.
  • La investigación futura debe centrarse en los métodos de reprogramación sin ovocitos.