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El genoma del virus de la hepatitis E en las heces de pacientes con hepatitis durante una gran epidemia en el norte
R Ray1, R Aggarwal, P N Salunke
1National Institute of Immunology, New Delhi, India.
Lancet (London, England)
|September 28, 1991
Resumen
El virus de la hepatitis E (VHE) se detectó en muestras de heces de una gran epidemia de hepatitis en el norte de la India. Este hallazgo sugiere fuertemente que el HEV fue la causa del brote generalizado.
Área de la Ciencia:
- Virología Virología.
- Enfermedades infecciosas Enfermedades infecciosas.
- Salud Pública La salud pública.
Sus antecedentes:
- La hepatitis E es una causa significativa de hepatitis aguda a nivel mundial, particularmente en los países en desarrollo.
- Se han reportado brotes de hepatitis a gran escala en varias regiones, lo que requiere investigaciones etiológicas.
Objetivo del estudio:
- Para investigar el agente causante de una gran epidemia de hepatitis en el norte de la India.
- Para detectar la presencia del genoma del virus de la hepatitis E (VHE) en pacientes afectados.
Principales métodos:
- Se recogieron muestras de heces de pacientes durante la epidemia de hepatitis.
- Se empleó la reacción en cadena de la transcripción-polimerasa inversa (RT-PCR) para detectar el genoma HEV.
Principales resultados:
- El genoma HEV se detectó en 6 de las 10 muestras de heces analizadas.
- Se observó una alta tasa de positividad para el genoma HEV en la cohorte de pacientes.
Conclusiones:
- La detección del genoma HEV proporciona una fuerte evidencia de su papel en la epidemia de hepatitis del norte de la India.
- Se confirma que el HEV es el agente etiológico responsable de este brote a gran escala.
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