Video Experimental Relacionado
Updated: Aug 13, 2026
08:20
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
¿Está el delirio postoperatorio relacionado con la reducción de triptófano en plasma?
R C van der Mast1, D Fekkes, P Moleman
1Department of Psychiatry, Dijkzigt Hospital, Rotterdam, Netherlands.
Lancet (London, England)
|October 5, 1991
Resumen
El delirio postoperatorio puede deberse a la reducción de la disponibilidad de triptófano en el cerebro. Este estudio encontró niveles más bajos de triptófano en plasma en pacientes que experimentaron delirio postcardiotómico, lo que sugiere un vínculo con el estado catabólico.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- La bioquímica es la bioquímica.
- Cirugía cardiovascular La cirugía cardiovascular es una cirugía cardiovascular.
Sus antecedentes:
- El delirio postoperatorio sigue siendo una complicación poco conocida.
- Los pacientes con cardiotomía corren el riesgo de desarrollar delirio.
Objetivo del estudio:
- Para investigar el papel del triptófano en el desarrollo del delirio postcardiotómico.
Principales métodos:
- Se midieron las concentraciones y proporciones plasmáticas de triptófano en 7 pacientes con delirio postcardiotómico.
- Se compararon estos niveles con 8 pacientes de control postoperatorio sin delirios.
Principales resultados:
- Los pacientes con delirio postcardiotómico mostraron concentraciones plasmáticas significativamente más bajas de triptófano.
- También se observó una proporción reducida de triptófano en plasma en el grupo de delirio.
Conclusiones:
- La disponibilidad reducida de triptófano cerebral, potencialmente debido a un estado catabólico, puede ser la causa de los síntomas mentales del delirio postcardiotómico.
- El metabolismo del triptófano podría ser un objetivo terapéutico para prevenir el delirio después de la cirugía cardíaca.
Videos de Conceptos Relacionados
01:26Psychosis: Goals of Pharmacotherapy
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
01:24Mania and Antimanic Drugs: Overview
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
01:28Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
01:23Antidepressant Drugs: MAOIs and Other Agents
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
01:23Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
A study on guinea pigs examined the...