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Remodelación del prospecto mitral en cardiomiopatía dilatada.
Tomasz A Timek1, David T Lai, Paul Dagum
1Department of Cardiothoracic Surgery, Stanford University School of Medicine Stanford, California 94305-5247, USA.
Circulation
|July 6, 2006
Resumen
La cardiomiopatía inducida por la taquicardia hace que los prospectos de la válvula mitral se alarguen debido a la remodelación cerca del borde, no al atado o al cambio de forma. Esta remodelación está relacionada con la regurgitación mitral en la cardiomiopatía.
Área de la Ciencia:
- Investigación cardiovascular Investigación cardiovascular Investigación cardiovascular Investigación cardiovascular Investigación cardiovascular
- Mecánica cardíaca La mecánica cardíaca.
- Ingeniería Biomédica Ingeniería Biomédica.
Sus antecedentes:
- Los prospectos de la válvula mitral de los mamíferos exhiben variaciones regionales en su composición y estructura.
- El impacto de la cardiomiopatía dilatada en la forma y geometría del folleto mitral sigue sin estar claro.
Objetivo del estudio:
- Para investigar cómo la cardiomiopatía inducida por taquicardia (TIC) afecta la forma de la válvula mitral, la geometría y la remodelación regional.
- Para determinar si se producen enlaces de folleto o cambios de forma significativos en la regurgitación mitral funcional (RFM) inducida por TIC.
Principales métodos:
- Marcadores radio-opacos implantados en el anillo mitral y folletos en nueve ovejas.
- Cardiomiopatía inducida y regurgitación mitral funcional a través del ritmo rápido.
- Utilizado biplano videofluoroscopia y ecocardiografía para medir la longitud del prospecto, las longitudes de segmentos, y el desplazamiento.
Principales resultados:
- La longitud total del prospecto mitral anterior (AML) y el prospecto mitral posterior (PML) aumentó significativamente después del ritmo.
- La remodelación regional significativa se observó solo en los segmentos de folleto cerca del borde (AML S4 y PML S5).
- No se detectaron cambios en la forma de la LMA o en el enlace del folleto.
Conclusiones:
- La cardiomiopatía inducida por taquicardia conduce al alargamiento del prospecto mitral a través de la remodelación regional en el borde del prospecto.
- La regurgitación mitral en la cardiomiopatía implica la remodelación del prospecto, desafiando la explicación puramente "funcional" de la RMF.
- Los hallazgos sugieren una base estructural para la regurgitación mitral en la cardiomiopatía más allá de la simple dilatación anular.
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