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La gastritis asociada a Helicobacter pylori y el linfoma gástrico primario de células B
A C Wotherspoon1, C Ortiz-Hidalgo, M R Falzon
1Department of Histopathology, University College and Middlesex School of Medicine, London, UK.
Lancet (London, England)
|November 9, 1991
Resumen
La infección por Helicobacter pylori puede conducir a tejido linfoide adquirido asociado a la mucosa gástrica (MALT). Este MALT adquirido es un precursor para el desarrollo del linfoma MALT gástrico, un cáncer de estómago común.
Área de la Ciencia:
- Gastroenterología y Gastroenterología.
- Oncología Oncología.
- Inmunología Inmunología.
Sus antecedentes:
- La mucosa gástrica normal carece de tejido linfoide, pero los linfomas gástricos primarios a menudo imitan el tejido linfoide asociado a la mucosa (MALT).
- Se adquiere tejido linfoide gástrico, típicamente en respuesta a la infección por Helicobacter pylori.
- La infección por Helicobacter pylori está fuertemente asociada con el desarrollo del linfoma MALT gástrico.
Objetivo del estudio:
- Para investigar la relación entre la infección por Helicobacter pylori y la adquisición de tejido linfoide gástrico.
- Para determinar la prevalencia de la infección por Helicobacter pylori en pacientes con linfoma MALT gástrico.
- Para establecer el papel del MALT gástrico adquirido en la patogénesis del linfoma MALT gástrico.
Principales métodos:
- Examen histopatológico de biopsias gástricas de 450 pacientes con gastritis asociada a H. pylori.
- Identificación de los folículos linfoides de la mucosa y la infiltración de los linfocitos B en el epitelio.
- Análisis del estado de la infección por H. pylori en 110 casos de linfoma MALT gástrico.
Principales resultados:
- 125 de 450 pacientes (27,8%) con gastritis por H. pylori mostraron folículos linfoides de la mucosa.
- 8 pacientes exhibieron infiltración de linfocitos B en el epitelio, una característica característica del MALT.
- La infección por Helicobacter pylori se detectó en 101 de los 110 casos de linfoma MALT gástrico (92%).
Conclusiones:
- El MALT gástrico se adquiere en respuesta a la infección por Helicobacter pylori.
- El MALT gástrico adquirido sirve como un trasfondo crucial para el desarrollo del linfoma MALT gástrico.
- La erradicación de H. pylori puede ser una estrategia potencial para prevenir el linfoma MALT gástrico.
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