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Influencia del tamaño de las plaquetas en el resultado después del infarto de miocardio
J F Martin1, P M Bath, M L Burr
1Department of Medicine, King's College School of Medicine and Dentistry, London, UK.
Lancet (London, England)
|December 7, 1991
Resumen
Un mayor volumen promedio de plaquetas (MPV), una medida del tamaño de las plaquetas, está relacionado con un mayor riesgo de muerte y ataques cardíacos recurrentes después de un ataque cardíaco. El recuento de plaquetas no mostró tal asociación, lo que sugiere que la MPV es un factor de riesgo independiente.
Área de la Ciencia:
- Cardiología Cardiología.
- Hematología Hematología.
Sus antecedentes:
- Las características de las plaquetas influyen en la enfermedad isquémica del corazón.
- La asociación entre el tamaño/número de plaquetas y los resultados después del infarto de miocardio (IM) no se entiende completamente.
Objetivo del estudio:
- Para investigar la relación entre el volumen promedio de plaquetas (MPV) y el recuento de plaquetas con la muerte y el reinfarto después de un índice MI.
Principales métodos:
- El VMP y el recuento de plaquetas se midieron en 1716 hombres seis meses después del infarto.
- Los resultados (muerte, eventos isquémicos recurrentes) se evaluaron durante dos años.
Principales resultados:
- Un MPV más alto se asoció significativamente con un mayor riesgo de eventos isquémicos fatales o no fatales (p < 0,001).
- Los hombres que murieron tenían un MPV significativamente mayor que los sobrevivientes (p < 0,001).
- No se observaron diferencias significativas en el recuento de plaquetas entre los grupos.
Conclusiones:
- MPV es un factor de riesgo independiente para el infarto de miocardio recurrente.
- El MPV, no el recuento de plaquetas, predice resultados adversos después del infarto de miocardio.
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