Video Experimental Relacionado
Updated: Jul 20, 2026
09:36
Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
Published on: October 16, 2010
Cambio de peso en adultos y riesgo de cáncer de mama postmenopáusico
A Heather Eliassen1, Graham A Colditz, Bernard Rosner
1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02115, USA. heather.eliassen@channing.harvard.edu
JAMA
|July 13, 2006
Resumen
El aumento de peso desde la edad adulta y la menopausia aumenta el riesgo de cáncer de mama en las mujeres posmenopáusicas. Mantener o perder peso después de la menopausia puede disminuir el riesgo de cáncer de mama, especialmente para las no usuarias de hormonas.
Área de la Ciencia:
- Endocrinología Endocrinología.
- Oncología Oncología.
- Epidemiología La epidemiología.
Sus antecedentes:
- Las hormonas endógenas son un conductor primario del cáncer de mama.
- La adiposidad influye en los niveles hormonales, especialmente en las mujeres posmenopáusicas, presentando un factor de riesgo potencialmente modificable para el cáncer de mama.
Objetivo del estudio:
- Investigar la asociación entre el cambio de peso en adultos (desde los 18 años y desde la menopausia) y el riesgo de cáncer de mama en mujeres posmenopáusicas.
Principales métodos:
- Estudio de cohorte prospectivo que utiliza datos del Estudio de Salud de las Enfermeras (87.143 mujeres posmenopáusicas).
- Cambio de peso evaluado desde los 18 años y desde la menopausia durante períodos de seguimiento prolongados (hasta 26 años).
- Monitoreo de la incidencia de cáncer de mama invasivo como resultado primario.
Principales resultados:
- Aumento significativo en el riesgo de cáncer de mama observado con un aumento sustancial de peso (≥25.0 kg desde los 18 años; ≥10.0 kg desde la menopausia).
- El aumento de peso desde la menopausia mostró una asociación más fuerte con el riesgo de cáncer de mama entre las mujeres que nunca usaron hormonas posmenopáusicas.
- La pérdida de peso (≥10,0 kg desde la menopausia) se asoció con una disminución del riesgo, especialmente en las no usuarias de hormonas.
Conclusiones:
- El aumento de peso en adultos, especialmente después de la menopausia, eleva el riesgo de cáncer de mama en mujeres posmenopáusicas.
- La pérdida de peso después de la menopausia está relacionada con la reducción del riesgo de cáncer de mama.
- Se recomienda mantener o lograr un peso saludable alrededor de la menopausia para reducir el riesgo de cáncer de mama.
Videos de Conceptos Relacionados
02:59Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
01:19The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:27Signs of Puberty
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
01:28Menopause
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
01:19Psychoneuroimmunology: Diabetes and Cancer
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...