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Corrección de la disfunción endotelial en la microcirculación coronaria de pacientes con hipercolesterolemia por
H Drexler1, A M Zeiher, K Meinzer
1Medizinische Klinik III, Universität Freiburg, Germany.
Lancet (London, England)
|December 21, 1991
Resumen
El colesterol alto perjudica la función de los vasos sanguíneos, reduciendo el flujo sanguíneo. La suplementación con L-arginina restauró con éxito el flujo sanguíneo normal en pacientes con hipercolesterolemia, lo que sugiere un tratamiento potencial para la disfunción endotelial.
Área de la Ciencia:
- Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
- Investigación de la función endotelial Investigación de la función endotelial
- Trastornos metabólicos Los trastornos metabólicos son trastornos metabólicos que se producen en el cuerpo.
Sus antecedentes:
- La hipercolesterolemia está relacionada con el deterioro de la función endotelial.
- La disfunción endotelial puede deberse a la reducción de la biodisponibilidad del óxido nítrico (NO), potencialmente debido a la deficiencia de L-arginina.
- La respuesta de la circulación coronaria a la hipercolesterolemia requiere más investigación.
Objetivo del estudio:
- Investigar si la L-arginina puede revertir la disfunción endotelial en pacientes con hipercolesterolemia.
- Para evaluar el impacto de la L-arginina en el flujo sanguíneo coronario y la función de la arteria epicárdica.
Principales métodos:
- El estudio incluyó a 8 pacientes con hipercolesterolemia y 7 controles.
- Diámetro medido de la arteria epicárdica y velocidad de flujo sanguíneo coronario.
- Se administra acetilcolina (agente dependiente del endotelio) y L-arginina por infusión intracoronaria.
Principales resultados:
- Los pacientes con hipercolesterolemia mostraron un aumento atenuado del flujo sanguíneo coronario inducido por acetilcolina en comparación con los controles.
- La infusión de L-arginina restauró el aumento inducido por la acetilcolina en el flujo sanguíneo coronario en pacientes con hipercolesterolemia.
- La L-arginina no afectó el flujo sanguíneo coronario en sujetos de control.
Conclusiones:
- La hipercolesterolemia afecta la dilatación dependiente del endotelio en la microcirculación coronaria.
- La administración a corto plazo de L-arginina puede revertir este deterioro.
- La L-arginina muestra potencial como agente terapéutico para la disfunción endotelial inducida por la hipercolesterolemia.
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