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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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Pruebas en animales. La marea se vuelve contra el LD50.

P Aldhous

    Nature
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    PubMed
    Resumen

    No abstract available in PubMed .

    Palabras clave:
    Investigaciones biomédicas y conductuales.Organización para la Cooperación y el Desarrollo Económicos.

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