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Updated: Jul 8, 2026
09:18
Spheroid Assay to Measure TGF-β-induced Invasion
Published on: November 16, 2011
ErbB2 hace que la integrina beta-4 sea cómplice en la tumorigénesis
1One Bungtown Road, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. muthuswa@cshl.edu
Cell
|August 12, 2006
Resumen
La integrina alfa 6 beta 4 y la señalización ErbB2 cooperan en la formación de tumores mamarios. Vías distintas regulan la proliferación celular y la adhesión aguas abajo de este complejo de ErbB2-integrina.
Área de la Ciencia:
- Biología celular Biología celular.
- Investigación de la investigación del cáncer.
- Se integra en la señalización.
Sus antecedentes:
- Las integrinas son receptores de la superficie celular que median las interacciones matriz célula-extracelular y célula-célula.
- Los receptores del factor de crecimiento, como ErbB2, juegan un papel crítico en el crecimiento y la supervivencia celular.
- La interacción entre las integrinas y los receptores del factor de crecimiento en la tumorigénesis sigue siendo incompletamente entendida.
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