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Updated: Jul 16, 2026

Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites
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La alquilación específica de la secuencia de la secuencia de repetición del telómero humano de doble hebra por

Shunta Sasaki1, Toshikazu Bando, Masafumi Minoshima

  • 1Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo, Kyoto, 606-8502, Japan.

Journal of the American Chemical Society
|September 14, 2006
PubMed
Resumen

Las nuevas poliamidas de horquilla de pirrol-imidazol (seco-CBI conjugados 1 y 2) se dirigen efectivamente a las secuencias de telómeros humanos. Estos compuestos muestran un potencial significativo como fármacos antitumorales debido a su potente alquilación del ADN y citotoxicidad contra las células cancerosas.

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