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Inhibidores azídicos orgánicos de las proteasas cisteína

Giang Thanh Le1, Giovanni Abbenante, Praveen K Madala

  • 1Centre for Drug Design and Development, Institute for Molecular Bioscience, University of Queensland, Brisbane, Qld 4072, Australia.

Journal of the American Chemical Society
|September 21, 2006
PubMed
Resumen

Los investigadores desarrollaron nuevos inhibidores de la cisteína proteasa utilizando un grupo azidometileno menos reactivo. Este enfoque ofrece una inhibición potente y reversible con una estabilidad mejorada y propiedades similares a las de los medicamentos, superando los efectos secundarios tóxicos de los inhibidores electrófilos tradicionales.

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