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Terapia génica: ¿es IL2RG oncogénico en el desarrollo de células T?

Karin Pike-Overzet1, Dick de Ridder, Floor Weerkamp

  • 1Department of Immunology, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands.

Nature
|September 22, 2006
PubMed
Resumen

La terapia génica de cadena gamma del receptor de interleucina-2 (IL2RG) para la inmunodeficiencia grave combinada ligada al X (X-SCID) puede no ser directamente oncogénica. En cambio, la señalización restaurada permite el desarrollo de células T, lo que permite a los oncogenes como LMO2 promover la leucemia.

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