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Videos de Conceptos Relacionados

Replication in Eukaryotes02:31

Replication in Eukaryotes

Overview
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Translesion DNA Polymerases02:10

Translesion DNA Polymerases

Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
TLS polymerases are found in all three domains of life - archaea, bacteria, and eukaryotes. Of the different classes of TLS polymerases, members of the Y family are fitted with specialized structures that...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.

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Attenuation of ATM signaling by ROS delays replicative senescence at physiological oxygen.

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How Shelterin Orchestrates the Replication and Protection of Telomeres.

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Replicative senescence is ATM driven, reversible, and accelerated by hyperactivation of ATM at normoxia.

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POT1 recruits and regulates CST-Polα/primase at human telomeres.

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Video Experimental Relacionado

Updated: Jul 7, 2026

In vitro Reconstitution of the Active T. castaneum Telomerase
09:25

In vitro Reconstitution of the Active T. castaneum Telomerase

Published on: July 14, 2011

Los laureles de Lasker para la telomerasa.

Titia de Lange1

  • 1Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA. delange@mail.rockefeller.edu <delange@mail.rockefeller.edu>

Cell
|September 23, 2006
PubMed
Resumen

La Fundación Lasker rinde homenaje a la telomerasa, una enzima crucial para mantener la estabilidad cromosómica y permitir la proliferación celular a largo plazo, destacando su importancia médica.

Área de la Ciencia:

  • La bioquímica es la bioquímica.
  • Biología Molecular Biología Molecular
  • Genética La genética.

Sus antecedentes:

  • La telomerasa es una enzima vital responsable de mantener la longitud de los telómeros.
  • El acortamiento de los telómeros está relacionado con el envejecimiento celular y la inestabilidad genómica.

Objetivo del estudio:

  • Para resaltar la importancia médica de la telomerasa.
  • Reconocer el papel de la telomerasa en la estabilidad cromosómica y la proliferación celular.

Principales métodos:

  • Revisión de la investigación existente sobre la función de la telomerasa.
  • Análisis del impacto de la telomerasa en los procesos celulares.

Principales resultados:

  • La actividad de la telomerasa es esencial para la supervivencia a largo plazo y la proliferación de las células.

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Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
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Telomerase Activity in the Various Regions of Mouse Brain: Non-Radioactive Telomerase Repeat Amplification Protocol (TRAP) Assay

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Last Updated: Jul 7, 2026

In vitro Reconstitution of the Active T. castaneum Telomerase
09:25

In vitro Reconstitution of the Active T. castaneum Telomerase

Published on: July 14, 2011

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
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Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

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Telomerase Activity in the Various Regions of Mouse Brain: Non-Radioactive Telomerase Repeat Amplification Protocol (TRAP) Assay
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  • La desregulación de la telomerasa está implicada en varias enfermedades.

    • Conclusiones:

    • La telomerasa es un objetivo clave para las intervenciones terapéuticas.
    • Comprender la telomerasa es fundamental para el avance de la medicina.