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Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
Published on: February 15, 2016
Asociación específica de secuencia en medios acuosos mediante la integración de enlaces de hidrógeno e interacciones
Minfeng Li1, Kazuhiro Yamato, Joseph S Ferguson
1Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Journal of the American Chemical Society
|September 28, 2006
Resumen
Los investigadores crearon duplexos de oligoamida con enlaces cruzados de disulfuro específicos de la secuencia en agua. Este método utiliza enlaces de disulfuro reversibles, lo que permite la asociación molecular en varios entornos.
Área de la Ciencia:
- Química supramolecular de las moléculas.
- Química orgánica es la química orgánica.
- Ciencia de los materiales Ciencia de los materiales.
Sus antecedentes:
- Las hebras de oligoamida forman naturalmente duplexos enlazados con hidrógeno específicos de la secuencia en disolventes no polares.
- Extender esta asociación molecular específica a los medios acuosos presenta un desafío significativo.
Objetivo del estudio:
- Desarrollar un método para crear duplexos de oligoamida enlazados específicos de la secuencia en medios acuosos.
- Demostrar la compatibilidad de estos sistemas en entornos polares y no polares.
Principales métodos:
- Incorporación de grupos tiol protegidos por tritilo en las hebras de oligoamida.
- Utilizando la formación de enlaces disulfuro reversibles para el enlace cruzado.
- Análisis utilizando MALDI-TOF y HPLC de fase inversa.
Principales resultados:
- Se han formado con éxito duplexos de oligoamida con enlaces cruzados de disulfuro en solución acuosa y metanol.
- Se demostró que el enlace cruzado ocurre solo entre secuencias complementarias de enlaces de hidrógeno.
- Se confirmó la especificidad de la secuencia a través de técnicas analíticas.
Conclusiones:
- La interacción de enlaces de hidrógeno e interacciones covalentes reversibles permite la asociación específica de secuencias en medios competitivos.
- Este enfoque produce una nueva clase de unidades de asociación y ligadura molecular.
- Estas unidades son compatibles con entornos polares y no polares.
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