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In Situ Detection of Autoreactive CD4 T Cells in Brain and Heart Using Major Histocompatibility Complex Class II Dextramers
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Epistasis funcional en un haplotipo común de MHC asociado con esclerosis múltiple

Jon W Gregersen1, Kamil R Kranc, Xiayi Ke

  • 1Department of Clinical Immunology, Aarhus University Hospital, Skejby Sygehus, 8200 N, Aarhus, Denmark.

Nature
|September 29, 2006
PubMed
Resumen

El haplotipo humano MHC HLA-DR2, vinculado a la esclerosis múltiple, exhibe un fuerte desequilibrio de vinculación potencialmente mantenido por la selección positiva. Una interacción funcional entre sus alelos puede explicar esto, ofreciendo información sobre la regulación de la respuesta inmune.

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