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Aumento de la actividad catalítica de la fosfolipasa C-gamma 1 por fosforilación de la tirosina

S Nishibe1, M I Wahl, S M Hernández-Sotomayor

  • 1Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.

Science (New York, N.Y.)
|November 30, 1990
PubMed
Resumen

La fosforilación por tirosina de la fosfolipasa C-gamma 1 (PLC-gamma 1) por el receptor del factor de crecimiento epidérmico (EGF) activa su actividad catalítica. Esta activación aumenta la transducción de la señal, lo que lleva a un aumento de la producción de inositol trifosfato y diacilglicerol.

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