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La citotoxina de la subtilase AB5 inactiva el chaperón del retículo endoplásmico BiP

Adrienne W Paton1, Travis Beddoe, Cheleste M Thorpe

  • 1School of Molecular and Biomedical Science, University of Adelaide, South Australia 5005, Australia. adrienne.paton@adelaide.edu.au

Nature
|October 7, 2006
PubMed
Resumen

La citotoxina subtilase, una toxina bacteriana, desencadena la muerte celular al dividir el chaperón esencial del retículo endoplasmático BiP/GRP78.8. Esta escisión específica interrumpe la función celular normal, lo que pone de relieve un nuevo mecanismo de patogénesis bacteriana.

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