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La expresión superficial del MHC clase II en células dendríticas está controlada por ubiquitinación regulada

Jeoung-Sook Shin1, Melanie Ebersold, Marc Pypaert

  • 1Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, PO Box 208002, New Haven, Connecticut 06520-8002, USA.

Nature
|October 20, 2006
PubMed
Resumen

Las células dendríticas regulan el MHC II superficial mediante el control de la ubiquitinación. Las células inmaduras ubiquitan el MHC II para la endocitosis, que se detiene al madurar, aumentando la presentación superficial del MHC II.

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