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Ciclotrimerización eficiente intermolecular [2 + 2 + 2] de alquino en medio acuoso utilizando un precatalizador de

Victorio Cadierno¹, Sergio E García-Garrido, José Gimeno

¹Departamento de Química OrgAnica e InorgAnica, Instituto Universitario de Química Organometálica Enrique Moles (Unidad Asociada al CSIC), Universidad de Oviedo, JuliAn Claveria 8, E-33006 Oviedo, Spain. vcm@uniovi.es

Journal of the American Chemical Society

|November 23, 2006

Resumen

Un nuevo complejo dimérico bis ((allyl) - rutenio ((IV) cataliza eficientemente la [2 + 2 + 2] ciclización de los alquinos. Esta reacción se produce en un medio acuoso, ofreciendo un enfoque sintético más ecológico.

Área de la Ciencia:

Química organometálica Química orgánica de los metales.
La catálisis de la catálisis.
Química verde es la química verde.

Sus antecedentes:

La ciclización [2 + 2 + 2] es una reacción vital para la síntesis de compuestos aromáticos sustituidos.
El desarrollo de catalizadores eficientes y respetuosos con el medio ambiente para esta transformación es un área de investigación clave.

Objetivo del estudio:

Para investigar la actividad catalítica de un complejo dimérico bis(allilo) - rutenio(IV) en la reacción de ciclización [2 + 2 + 2].
Explorar el uso de un medio acuoso para esta importante transformación orgánica.

Principales métodos:

Síntesis y caracterización del complejo dimérico bis (((alil) - rutenio ((IV)) [{Ru(eta3:eta3-C10H16) ((mu-Cl) Cl}2].
Evaluación del rendimiento catalítico del complejo en la [2 + 2 + 2] ciclización de varios alquinas terminales e internos.
Optimización de la reacción en un medio acuoso.

Principales resultados:

El complejo dimérico bis (((allilo) - rutenio ((IV) demostró una alta eficiencia catalítica para la ciclización [2 + 2 + 2].
La reacción procedió efectivamente en un medio acuoso, destacando la estabilidad y actividad del complejo en el agua.
Una serie de alquinas terminales e internas fueron cicladas con éxito, produciendo diversos productos aromáticos.

Conclusiones:

El complejo dimérico bis ((allyl) - rutenio ((IV) es un catalizador altamente efectivo para la ciclización [2 + 2 + 2] de alquinos.
El desarrollo de este sistema catalítico en medios acuosos representa un avance significativo en la química sintética verde.

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