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Resolución de los ésteres quirales de fosfato, fosfonato y fosfinato por una biblioteca de enzimas enantioselectivas

Charity Nowlan1, Yingchun Li, Johannes C Hermann

  • 1Department of Chemistry, Texas A&M University, College Station, Texas 77842-3012, USA.

Journal of the American Chemical Society
|December 7, 2006
PubMed
Resumen

Las enzimas bacterianas de la fosfotriesterasa pueden ser diseñadas para descomponer selectivamente los ésteres quirales de fosfato, fosfonato y fosfinato. Las mutaciones alteran dramáticamente la selectividad de las enzimas, permitiendo la resolución cinética de diversos compuestos químicos.

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