Video Experimental Relacionado
Updated: Jul 29, 2026
09:18
Detection of Heterodimerization of Protein Isoforms Using an in Situ Proximity Ligation Assay
Published on: October 20, 2018
Alineación quiral de los cromóforos OPV: explotación del foldamer basado en ureidoftalimida
Renatus W Sinkeldam1, Freek J M Hoeben, Maarten J Pouderoijen
1Contribution from the Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.
Journal of the American Chemical Society
|December 15, 2006
Resumen
Este estudio demuestra cómo la elección del disolvente influye en la quiralidad supramolecular de los foldameres de poli (ureaidoftalimida) decorados con cromóforos de oligo (p-fenileno vinileno) (OPV). Los hallazgos resaltan la expresión de la estructura secundaria dependiente del disolvente en el autoensamblaje del pliegue.
Área de la Ciencia:
- Química supramolecular de las moléculas.
- La ciencia de los polímeros es la ciencia de los polímeros.
- Química orgánica es la química orgánica.
Sus antecedentes:
- Los Foldamers son polímeros sintéticos que imitan las estructuras secundarias de las biomoléculas naturales.
- Los foldameres poli ((ureidoftalimida) sirven como andamios para la organización de grupos funcionales.
- Los cromóforos oligo ((p-fenileno vinileno) (OPV) se utilizan por sus propiedades ópticas.
Objetivo del estudio:
- Para investigar la organización quiral de los cromóforos de OPV en un andamio de foldamer poli (ureaidoftalimida).
- Explorar la influencia del disolvente en la estructura secundaria y la quiralidad supramolecular de estos foldameres.
- Para caracterizar el comportamiento de autoensamblaje de los conjugados plegable-cromóforo.
Principales métodos:
- Síntesis de bloques de construcción de foldamer decorados con OPV y posterior polimerización.
- Separación de las cadenas de polímeros por cromatografía.
- Espectroscopia de dicroísmo circular (CD) para estudiar la estructura secundaria y la quiralidad.
- Microscopía de túnel de barrido (STM) para visualizar arquitecturas autoensambladas.
Principales resultados:
- Las arquitecturas helicoidales con varios giros se construyeron utilizando cadenas plegables más largas.
- Los estudios de dicroísmo circular revelaron arreglos helicoidales dependientes del disolvente de los OPV (observados en THF, no en CHCl3).
- Un efecto de algodón bisignato en el heptano indicó la expresión de quiralidad supramolecular, dependiendo de la historia del disolvente (THF vs. CHCl3).
- El análisis del STM mostró arquitecturas circulares formadas por oligómeros más cortos en la interfaz de grafito/1-feniloctano.
Conclusiones:
- El disolvente juega un papel crítico en dictar la expresión de la quiralidad supramolecular dentro de la estructura secundaria del foldamer.
- El andamio foldamer organiza efectivamente los cromóforos OPV, lo que lleva a ensamblajes quirales sensibles al disolvente.
- El comportamiento de autoensamblaje observado es consistente con las conformaciones plegadas propuestas de los foldamers decorados.
Videos de Conceptos Relacionados
02:52Stereoisomerism
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
03:00Molecular Chaperones and Protein Folding
The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
The...
The...
02:25Chirality
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
02:18Fischer Projections
Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines. While...
02:05Prochirality
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
02:30Chirality in Nature
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid. The...