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La homocisteína elevada se asocia con una función ventricular izquierda regional reducida: el estudio multiétnico de
Khurram Nasir1, Michael Tsai, Boaz D Rosen
1Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA.
Circulation
|January 4, 2007
Resumen
Los niveles elevados de homocisteína (Hcy) están relacionados con la reducción de la función sistólica regional del ventrículo izquierdo en individuos asintomáticos. Este hallazgo sugiere que Hcy puede afectar la salud cardíaca incluso antes de que aparezcan los síntomas.
Área de la Ciencia:
- Cardiología Cardiología.
- La bioquímica es la bioquímica.
- Imágenes médicas de imágenes médicas.
Sus antecedentes:
- La homocisteína elevada (Hcy) es un factor de riesgo potencial para la insuficiencia cardíaca congestiva.
- Estudios previos sugieren un vínculo entre Hcy y la enfermedad cardíaca en poblaciones específicas.
Objetivo del estudio:
- Investigar la asociación entre los niveles de homocisteína y la función ventricular izquierda regional.
- Para evaluar la función cardíaca en una población asintomática utilizando técnicas avanzadas de imagen.
Principales métodos:
- Utilizó imágenes de resonancia magnética (IRM) etiquetadas en 1178 participantes del Estudio Multiétnico de Aterosclerosis (MESA).
- Las cepas circunferenciales de la pared media sistólica de pico regional calculadas, que definen las regiones ventriculares izquierdas por territorios coronarios.
- Ajustado para los factores de riesgo cardiovasculares tradicionales, los datos demográficos y las medidas de aterosclerosis.
Principales resultados:
- Se observó un acortamiento circunferencial miocárdico regional reducido en los territorios descendentes anteriores izquierdos y en el circunflejo izquierdo en relación con los niveles plasmáticos de Hcy.
- La disfunción sistólica circundante mostró una asociación significativa con niveles elevados de Hcy transformado en logaritmos en estas regiones.
- Se encontraron mayores probabilidades de cepas ventriculares izquierdas reducidas con niveles más altos de Hcy en todas las regiones de la arteria coronaria analizadas.
Conclusiones:
- Los niveles elevados de homocisteína se asocian con una disminución de la función sistólica ventricular izquierda regional en una cohorte asintomática.
- La resonancia magnética puede detectar reducciones sutiles en la función cardíaca relacionadas con Hcy.
- Estos hallazgos destacan Hcy como un biomarcador potencial para el deterioro cardíaco subclínico.
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