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Neurofisiología: el modelo de Hodgkin y Huxley, ¿todavía está en pie?
David A McCormick1, Yousheng Shu, Yuguo Yu
1Department of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA. david.mccormick@yale.edu
Nature
|January 5, 2007
Resumen
Los potenciales de acción en las neuronas corticales tienen umbrales variables. Los modelos complejos de Hodgkin-Huxley explican estas características considerando la geometría neuronal, no las propiedades exóticas del canal.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- La neurociencia computacional es una neurociencia computacional.
- La biofísica es la biofísica.
Sus antecedentes:
- Los potenciales de acción en las neuronas corticales exhiben umbrales variables y una rápida despolarización.
- Los modelos de Hodgkin-Huxley de compartimiento único o doble existentes luchan por replicar estas características.
- Las hipótesis previas proponían el encierro cooperativo del canal de sodio (Na+), sin evidencia biológica directa.
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01:41Action Potentials
Overview
01:14Action Potential
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01:14Action Potential
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
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Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...