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A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
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La alfa-alquinilación organocatalítica asimétrica directa y directa de los beta-cetoésteres cíclicos

Thomas B Poulsen1, Luca Bernardi, José Aleman

  • 1Department of Chemistry, Center for Catalysis, Danish National Research Foundation, Aarhus University, DK-8000 Aarhus C, Denmark.

Journal of the American Chemical Society
|January 11, 2007
PubMed
Resumen

Este estudio introduce la primera alfa-alquinilación organocatalítica enantioselectiva directa de beta-cetoesters y 3-ácilo oxindoles utilizando catalizadores quirales de transferencia de fase. El método logra altos rendimientos y excelentes enantioselectividades para varios sustratos.

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