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Participación de PKC postsináptico en la depresión cerebelosa a largo plazo en cultivo

D J Linden1, J A Connor

  • 1Department of Neurosciences, Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110.

Science (New York, N.Y.)
|December 13, 1991
PubMed
Resumen

La activación de la proteína quinasa C (PKC) es esencial para inducir la depresión a largo plazo (LTD) en las neuronas Purkinje cerebelares. La inhibición de la PKC bloquea la LTD, mientras que su activación imita la depresión de la eficacia sináptica.

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