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Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
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Comentario a "Una variante genética común se asocia con la obesidad en adultos y niños"
Christian Dina1, David Meyre, Chantal Samson
1CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France. dina@good.ibl.fr
Science (New York, N.Y.)
|January 16, 2007
Resumen
Un estudio anterior relacionó la variante del gen INSIG2 rs7566605 con la obesidad. Sin embargo, este gran estudio de replicación en individuos caucásicos no encontró una asociación significativa, lo que cuestiona el papel de la variante en la obesidad.
Área de la Ciencia:
- Genética La genética.
- Investigación de la obesidad.
- Estudios de poblaciones humanas Estudios de poblaciones humanas.
Sus antecedentes:
- Un informe previo sugirió un vínculo entre la variante del gen INSIG2 (rs7566605) y la obesidad.
- La asociación propuesta se basó en un modelo genético recesivo en cuatro poblaciones distintas.
Objetivo del estudio:
- Para replicar los hallazgos de Herbert et al. con respecto a la variante del gen INSIG2 rs7566605 y su asociación con la obesidad.
- Investigar el papel de esta variante genética específica en una cohorte caucásica más grande y diversa.
Principales métodos:
- Un estudio de replicación a gran escala en el que participaron 10.265 personas caucásicas.
- Incluir diseños de estudio basados en la familia, casos de control y población general.
- El análisis se centró en la variante del gen INSIG2 rs7566605.5.
Principales resultados:
- No se encontró una asociación significativa entre la variante del gen INSIG2 rs7566605 y la obesidad en la población caucásica estudiada.
- Los resultados no apoyaron un papel importante para esta variante genética específica en el desarrollo de la obesidad.
- El intento de replicación no pudo confirmar la asociación previamente reportada.
Conclusiones:
- La variante del gen INSIG2 rs7566605 no parece desempeñar un papel importante en la obesidad entre los individuos caucásicos.
- Puede ser necesaria más investigación para explorar otros factores genéticos o ambientales que contribuyen a la obesidad.
- La asociación inicial reportada requiere una interpretación cautelosa dados estos hallazgos de replicación.
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