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¿Son los aneurismas aórticos causados por la aterosclerosis?
D Reed1, C Reed, G Stemmermann
1Honolulu Heart Program, HI 96817.
Circulation
|January 1, 1992
Resumen
Los factores de riesgo de aterosclerosis como la presión arterial alta, el colesterol y el tabaquismo están relacionados con la mayoría de los aneurismas aórticos. Este estudio de 20 años sugiere que la aterosclerosis es un factor clave en el desarrollo del aneurisma.
Área de la Ciencia:
- Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
- Epidemiología La epidemiología.
- Patología Patología Patología.
Sus antecedentes:
- Investigó el controvertido papel de la aterosclerosis en el desarrollo del aneurisma aórtico.
- Utilizó datos de seguimiento de 20 años de más de 8,000 hombres de ascendencia japonesa en Hawái.
Objetivo del estudio:
- Examinar la relación entre los factores de riesgo de aterosclerosis y la incidencia de aneurismas aórticos y disecciones.
- Para determinar si la aterosclerosis es un componente necesario en la vía causal de los aneurismas aórticos.
Principales métodos:
- Análisis de eventos de incidentes clínicos (aneurismas aórticos y disecciones) y datos de la autopsia.
- Factores de riesgo basal identificados para la aterosclerosis aórtica y los aneurismas.
- Factores de riesgo comparados para los aneurismas aórticos frente a las disecciones aórticas.
Principales resultados:
- Se identificaron 151 aneurismas aórticos y 23 disecciones aórticas entre 174 eventos clínicos.
- Los factores de riesgo iniciales para los aneurismas aórticos (hipertensión, colesterol alto, tabaquismo) reflejaron los de la aterosclerosis aórtica.
- Estos factores de riesgo también se asociaron con aneurismas aórticos en hombres autopsiados.
- Las disecciones aórticas mostraron una incidencia específica por edad, lo que sugiere una susceptibilidad innata y otros factores precipitantes, principalmente predichos por la hipertensión.
Conclusiones:
- Es probable que los factores de riesgo de aterosclerosis sean necesarios para el desarrollo de la mayoría de los aneurismas aórticos en esta cohorte.
- La aterosclerosis en sí misma parece ser un elemento crítico en la vía causal de la mayoría de los aneurismas aórticos.
- Los hallazgos tienen implicaciones para la prevención de los aneurismas aórticos al dirigirse a la aterosclerosis.
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