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Microfluidic Mixers for Studying Protein Folding
Published on: April 10, 2012
Biología estructural: análisis del plegamiento "descendiente" de las proteínas
Neil Ferguson1, Timothy D Sharpe, Christopher M Johnson
1Medical Research Council Centre for Protein Engineering, Medical Research Council Centre, Cambridge CB2 2QH, UK. arf25@cam.ac.uk
Nature
|February 16, 2007
Resumen
Las pequeñas proteínas de la familia de dominios de unión de subunidades periféricas pueden no doblarse "descendiendo". La evidencia actual es insuficiente para apoyar las afirmaciones de plegado no cooperativo para versiones truncadas como Naf-BBL.
Área de la Ciencia:
- Dinámica del plegamiento de las proteínas.
- La biofísica es la biofísica.
- Biología estructural Biología estructural.
Sus antecedentes:
- Investigar los mecanismos de plegamiento de las pequeñas proteínas es crucial para comprender la función biológica.
- La familia de dominios de unión de la subunidad periférica está implicada en varios procesos celulares.
- Existe controversia con respecto a las vías de plegamiento de estas proteínas, específicamente el "descenso" frente al plegamiento cooperativo.
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