Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation.

Cell stem cell·2026
Same author

Multiomic analyses delineate human neuroendocrine tumor cell states in relation to normal enteroendocrine cell ontogeny.

The Journal of clinical investigation·2026
Same author

Loss of tumor-infiltrating lymphocytes and poor response to immunotherapy in IDH GOF mutant melanoma.

JCI insight·2026
Same author

Distinctive DNA sequence features define epigenetic longevity of inflammatory memory.

Science (New York, N.Y.)·2026
Same author

The DNA methylation landscape of naturally short-lived killifish.

Scientific reports·2026
Same author

Non-disruptive in vitro monitoring of cellular states with cell-free DNA methylation.

Genome biology·2026

Video Experimental Relacionado

Updated: May 11, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

El epigenoma de los mamíferos.

Bradley E Bernstein1, Alexander Meissner, Eric S Lander

  • 1Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA. bbernstein@partners.org

Cell
|February 27, 2007
PubMed
Resumen
Este resumen es generado por máquina.

El epigenoma, que abarca cambios hereditarios en el ADN y las proteínas histónicas, regula la función del genoma. Comprender su composición compleja es crucial para descifrar la expresión génica en diversos contextos biológicos.

Más Videos Relacionados

Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina
07:50

Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina

Published on: August 29, 2018

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

Videos de Experimentos Relacionados

Last Updated: May 11, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina
07:50

Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina

Published on: August 29, 2018

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

Área de la Ciencia:

  • La genómica es la genómica.
  • Biología Molecular Biología Molecular
  • La epigenética es la epigenética.

Sus antecedentes:

  • Las modificaciones químicas en el ADN y las proteínas histónicas crean una red reguladora que controla la estructura de la cromatina y la función del genoma.
  • El epigenoma representa cambios hereditarios en todo el genoma, influenciados por la genética, el linaje celular y el medio ambiente.
  • Secuenciación del genoma post-humano, la investigación se centra en la comprensión de los cambios epigenéticos en la expresión génica a través del desarrollo, los tejidos y las enfermedades.

Objetivo del estudio:

  • Revisar los esfuerzos de investigación actuales en los estudios del epigenoma.
  • Para resaltar estudios a gran escala, tecnologías emergentes y desafíos en la investigación del epigenoma.
  • Proporcionar una visión integral de las modificaciones epigenéticas y su papel en la función del genoma.

Principales métodos:

  • Revisión de la literatura actual y estudios de epigenoma a gran escala.
  • Se hace hincapié en las tecnologías emergentes para el análisis del epigenoma.
  • Análisis de los factores que influyen en la composición del epigenoma.

Principales resultados:

  • El epigenoma es una capa dinámica de regulación crucial para la interpretación de la información genética.
  • Los estudios a gran escala son esenciales para una comprensión completa de la variación del epigenoma.
  • Los avances tecnológicos están mejorando la capacidad de mapear y analizar el epigenoma.

Conclusiones:

  • Una comprensión completa del epigenoma es fundamental para el avance de la investigación biológica y médica.
  • La investigación futura debe centrarse en la integración de datos a gran escala y nuevas tecnologías.
  • Abordar los desafíos en la investigación del epigenoma desbloqueará nuevos conocimientos sobre la salud y la enfermedad.