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La epigenómica del cáncer

Peter A Jones¹, Stephen B Baylin

¹Department of Urology, Biochemistry, and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. jones_p@ccnt.usc.edu

|February 27, 2007

Resumen

Las anomalías epigenéticas, junto con los cambios genéticos, impulsan el desarrollo del cáncer desde las primeras etapas. Comprender estos cambios epigenéticos ofrece nuevas estrategias para el control del cáncer.

Área de la Ciencia:

Oncología Oncología.
La epigenética es la epigenética.
Biología Molecular Biología Molecular

Sus antecedentes:

El cáncer se caracteriza por una función genética y patrones de expresión aberrantes.
Las anomalías epigenéticas adquiridas contribuyen a la desregulación genética relacionada con el cáncer junto con las alteraciones genéticas.

Objetivo del estudio:

Revisar los avances recientes en la comprensión del papel de las alteraciones epigenéticas en la neoplasia temprana.
Discutir las implicaciones de estos avances para las estrategias de control del cáncer.

Principales métodos:

Revisión de la literatura de los avances científicos recientes.
Análisis del papel de las alteraciones epigenéticas en el desarrollo del cáncer.
Examen de las contribuciones de las células madre/precursoras a la neoplasia.

Principales resultados:

Las anomalías epigenéticas son cada vez más reconocidas como actores críticos en la iniciación del cáncer.
Estas alteraciones interactúan con los cambios genéticos para desregular la expresión génica.
Las células madre y precursoras están implicadas en las primeras etapas del desarrollo neoplásico debido a factores epigenéticos.

Conclusiones:

Las alteraciones epigenéticas son fundamentales para las primeras etapas del desarrollo del cáncer.
Los avances en la comprensión de la epigenética proporcionan nuevas vías para la prevención y el tratamiento del cáncer.

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