Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Chirality02:25

Chirality

Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
Fischer Projections02:18

Fischer Projections

Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines. While...
Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
Prochirality02:05

Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

One chromatin, many structures: From ensemble contact maps to single-cell 3D organization.

Biophysical journal·2026
Same author

Silver exchange dynamics in monolayer-protected doped gold clusters.

Nanoscale·2026
Same author

Disaggregation of Self-Assembling Molecules for Efficient Inverted Perovskite Solar Cells.

ACS nano·2026
Same author

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Adsorption modes of cysteine on gold: from neutral molecules to unconventional zwitterions.

Physical chemistry chemical physics : PCCP·2025
Same author

Geometrically encoded positioning of introns, intergenic segments, and exons in the human genome.

bioRxiv : the preprint server for biology·2025

Video Experimental Relacionado

Updated: Jul 9, 2026

Spatial Separation of Molecular Conformers and Clusters
10:37

Spatial Separation of Molecular Conformers and Clusters

Published on: January 9, 2014

Separación quiral: modelado de mecanismos en sistemas bidimensionales.

Irina Paci1, Igal Szleifer, Mark A Ratner

  • 1Department of Chemistry and Materials Research Center, Northwestern University, Evanston, Illinois 60208, USA. ipaci@chem.northwestern.edu

Journal of the American Chemical Society
|March 7, 2007
PubMed
Resumen

Una superficie achiral puede inducir la separación quiral en los racemates al restringir las configuraciones moleculares. El control de las interacciones promueve el autoensamblaje en grupos homoquirales, superando las limitaciones racémicas masivas.

Más Videos Relacionados

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
08:51

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Published on: August 18, 2017

Multimodal Nonlinear Hyperspectral Chemical Imaging Using Line-Scanning Vibrational Sum-Frequency Generation Microscopy
08:49

Multimodal Nonlinear Hyperspectral Chemical Imaging Using Line-Scanning Vibrational Sum-Frequency Generation Microscopy

Published on: December 1, 2023

Videos de Experimentos Relacionados

Last Updated: Jul 9, 2026

Spatial Separation of Molecular Conformers and Clusters
10:37

Spatial Separation of Molecular Conformers and Clusters

Published on: January 9, 2014

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
08:51

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Published on: August 18, 2017

Multimodal Nonlinear Hyperspectral Chemical Imaging Using Line-Scanning Vibrational Sum-Frequency Generation Microscopy
08:49

Multimodal Nonlinear Hyperspectral Chemical Imaging Using Line-Scanning Vibrational Sum-Frequency Generation Microscopy

Published on: December 1, 2023

Área de la Ciencia:

  • Química Física es la química física.
  • Ciencias de la superficie Ciencias de la superficie.
  • Estudios de Quiralidad Estudios de Quiralidad

Sus antecedentes:

  • La separación de la fase fluida de los racimas es un reto debido a las débiles interacciones intermoleculares quirales.
  • Las superficies pueden alterar las interacciones moleculares, lo que potencialmente permite la separación quiral.
  • Comprender la ruptura de simetría quiral inducida por la superficie es crucial para las tecnologías de separación.

Objetivo del estudio:

  • Investigar la ruptura de simetría quiral en racematos inducida por una superficie achiral.
  • Explorar el papel de la geometría molecular y la energética en las separaciones quirales confinadas en la superficie.
  • Determinar las condiciones para lograr la formación de racimos homoquirales.

Principales métodos:

  • Utilizó un algoritmo de Monte Carlo de templado paralelo con templado de dominio de temperatura.
  • Simuló un sistema bidimensional de moléculas quirales que interactúan con una superficie achiral.
  • Analizó el equilibrio entre las interacciones electrostáticas y estéricas.

Principales resultados:

  • Las superficies achirales pueden promover la segregación quiral en los racemates al restringir el espacio de configuración.
  • El control de las interacciones electrostáticas y estéricas dirige el ensamblaje en grupos micelares homoquirales.
  • Incluso con moléculas complejas que favorecen a los pares heteroquirales, los efectos multicorpos y entrópicos aún pueden producir micelas homoquirales.

Conclusiones:

  • El confinamiento superficial es una estrategia viable para lograr separaciones quirales de los racemates.
  • La forma molecular, las interacciones electrostáticas y estéricas gobiernan colectivamente el ensamblaje quiral inducido por la superficie.
  • Predecir la segregación de racemato requiere considerar los efectos multicorpo y entrópicos más allá de las interacciones en pares.