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La cardioprotección de la adiponectina después de la isquemia / reperfusión miocárdica implica la reducción del
Ling Tao1, Erhe Gao, Xiangying Jiao
1Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Circulation
|March 7, 2007
Resumen
La adiponectina protege el corazón de la lesión por isquemia/reperfusión al reducir el estrés oxidativo y la inflamación. Este estudio revela que la adiponectina es
Área de la Ciencia:
- Cardiología Cardiología.
- Endocrinología Endocrinología.
- Biología Molecular Biología Molecular
Sus antecedentes:
- Los niveles de adiponectina se reducen en pacientes con diabetes tipo 2.
- Los niveles de adiponectina se correlacionan inversamente con el riesgo de isquemia miocárdica.
Objetivo del estudio:
- Para aclarar el mecanismo de los efectos protectores de la adiponectina contra la isquemia miocárdica / lesión por reperfusión.
Principales métodos:
- Comparación del tamaño del infarto de miocardio, la apoptosis y los marcadores de estrés oxidativo en adiponectina knockout y ratones de tipo salvaje sometidos a isquemia/reperfusión.
- Evaluación de la inducible síntesis de óxido nítrico (iNOS) y la expresión de la proteína gp91 (((phox).
- Evaluación de los efectos de la administración del dominio globular de la adiponectina.
Principales resultados:
- La deficiencia de adiponectina aumentó notablemente la apoptosis miocárdica y el tamaño del infarto.
- Aumento de la formación de óxido nítrico (NO), superóxido y peroxinitrito en ratones con deficiencia de adiponectina.
- La administración de adiponectina redujo el estrés oxidativo inducido por isquemia/reperfusión y protegió contra lesiones cardíacas.
Conclusiones:
- La adiponectina es una molécula cardioprotectora natural contra las lesiones por isquemia/reperfusión.
- La adiponectina inhibe el iNOS y la NADPH-oxidasa, reduciendo el estrés oxidativo/nitrativo.
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