Infecciones que complican la micosis fungoides y el síndrome de Sézary
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Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
P I Axelrod1, B Lorber, E C Vonderheid
1Department of Medicine, Temple University School of Medicine, Philadelphia, PA.
JAMA
|March 11, 1992
Resumen
Los pacientes con micosis fungoides y el síndrome de Sézary con frecuencia desarrollan infecciones, principalmente infecciones bacterianas cutáneas. La etapa avanzada de la enfermedad es el factor de riesgo clave para infecciones graves y muerte, y las infecciones nosocomiales representan una amenaza significativa.
Área de la Ciencia:
- Dermatología Dermatología dermatología.
- Enfermedades infecciosas Enfermedades infecciosas.
- Oncología Oncología.
Sus antecedentes:
- La micosis fungoides (MF) y el síndrome de Sézary (SS) son linfomas cutáneos de células T con una morbilidad significativa.
- Las infecciones son una preocupación importante para los pacientes con sistemas inmunológicos comprometidos debido a estas condiciones.
Objetivo del estudio:
- Investigar la incidencia y los tipos de infecciones en pacientes con MF y SS.
- Evaluar el papel de las infecciones nosocomiales e identificar los factores de riesgo epidemiológico para las infecciones cutáneas y viscerales.
Principales métodos:
- Estudio de cohorte de inicio retrospectivo.
- Análisis de 356 pacientes con MF o SS.
- Análisis multivariado de la relación de riesgo para factores demográficos y clínicos.
Principales resultados:
- Las infecciones bacterianas cutáneas fueron las más comunes (17,0/100 pacientes-año).
- Las infecciones nosocomias comprendieron una proporción significativa de bacteriemia (59%), neumonía (62%) e infecciones fatales (88%).
- La participación del linfoma extracutáneo fue el principal factor de riesgo de infecciones graves y muerte.
Conclusiones:
- Las infecciones bacterianas de la piel adquiridas en la comunidad son comunes, pero por lo general son manejables.
- La bacteriemia nosocomial y la neumonía son las principales causas infecciosas de mortalidad.
- La etapa avanzada de la enfermedad es el predictor más crítico del riesgo de infección.
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