Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

65.0K
Overview
65.0K
Cell Migration01:19

Cell Migration

6.1K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.1K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

3.4K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.4K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

6.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
6.9K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

13.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
13.7K
T Cell Types and Functions01:24

T Cell Types and Functions

3.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.2K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same authorSame journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same author

Immune regeneration: implications for cancer immunotherapy and beyond.

The Journal of clinical investigation·2025
Same author

Reciprocal transmission of activating and inhibitory signals and cell fate in regenerating T cells.

Cell reports·2023
Same author

PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors.

Science immunology·2023
Same author

The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity.

Cancer cell·2023
Same author

Self-Renewing CD8+ T-cell Abundance in Blood Associates with Response to Immunotherapy.

Cancer immunology research·2022
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: May 6, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

7.5K

El desarrollo en movimiento: las células T auxiliares en el trabajo.

Steven L Reiner1

  • 1Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. sreiner@mail.med.upenn.edu <sreiner@mail.med.upenn.edu>

Cell
|April 10, 2007
PubMed
Resumen
Este resumen es generado por máquina.

Las células T auxiliares (células T auxiliares) son cruciales para la inmunidad, pero pueden causar enfermedades autoinmunes. Los nuevos descubrimientos, como el linaje celular Th17, añaden complejidad a la comprensión de las respuestas inmunes y su regulación.

Más Videos Relacionados

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

8.1K
Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
08:21

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

Published on: October 2, 2018

6.2K

Videos de Experimentos Relacionados

Last Updated: May 6, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

7.5K
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

8.1K
Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
08:21

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

Published on: October 2, 2018

6.2K

Área de la Ciencia:

  • Inmunología Inmunología.
  • Biología celular Biología celular.
  • Biología Molecular Biología Molecular

Sus antecedentes:

  • Las células T auxiliares son críticas para orquestar la defensa inmune contra los patógenos en los mamíferos.
  • Las células T ayudantes disfuncionales contribuyen a las enfermedades autoinmunes y alérgicas.
  • El descubrimiento de nuevos linajes celulares T-helper, como Th17, pone de relieve la complejidad de la regulación inmune.

Objetivo del estudio:

  • Explorar las funciones complejas de las células T auxiliares en la inmunidad y la autoinmunidad.
  • Comprender cómo las redes de señalización y transcripción influyen en el destino de las células T-helper.
  • Reevaluar la generación de respuestas inmunes apropiadas e inadecuadas.

Principales métodos:

  • Revisión de hallazgos recientes en la diferenciación y función de las células T.
  • Análisis de las vías de señalización involucradas en la determinación del destino de las células T auxiliares.
  • Examen de las redes de transcripción que gobiernan las respuestas inmunes.

Principales resultados:

  • Las células T ayudantes juegan un doble papel en la defensa y la autoinmunidad.
  • El linaje Th17 representa una adición significativa a la diversidad conocida de células T auxiliares.
  • Las redes de señalización y transcripción son determinantes clave de los resultados inmunológicos.

Conclusiones:

  • Comprender la plasticidad de las células T ayudantes es esencial para el manejo de enfermedades relacionadas con el sistema inmunológico.
  • Descubrimientos recientes están remodelando el marco conceptual de la regulación inmune.
  • Una mayor investigación sobre las redes de células T iluminará los mecanismos de la salud y la enfermedad.