Video Experimental Relacionado

Updated: Jul 15, 2026

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
07:38

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s

Published on: September 25, 2017

La reacción del citocromo P450BM3 y el peroxinitrito produce el complejo nitrosil

Rachel K Behan1, Lee M Hoffart, Kari L Stone

  • 1Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.

Journal of the American Chemical Society
|April 17, 2007
PubMed
Resumen

Peroxynitrite inactiva las proteínas, pero el intermediario formado en P450BM3 es un complejo de hierro-nitrosil, no un intermediario de ferril. Este hallazgo tiene un impacto en la comprensión de los mecanismos de la enfermedad que implican el daño de las proteínas.

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