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Comentario sobre "Evolución adaptativa en curso de ASPM, un determinante del tamaño del cerebro en el Homo sapiens"
Fuli Yu1, R Sean Hill, Stephen F Schaffner
1Department of Genetics, Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Science (New York, N.Y.)
|April 21, 2007
Resumen
El gen ASPM, vinculado a la microcefalia, puede no haber sufrido selección natural. Las comparaciones empíricas muestran que su variación no es inusual, desafiando los hallazgos anteriores basados en simulaciones.
Área de la Ciencia:
- Genética humana Genética humana es la genética humana.
- Biología evolutiva Biología evolutiva.
- Genética de poblaciones genética de poblaciones.
Sus antecedentes:
- El gen ASPM está asociado con microcefalia, una condición caracterizada por un cerebro anormalmente pequeño.
- Investigaciones anteriores sugirieron que la ASPM experimentó una selección natural en los humanos en los últimos 14.100 años.
Objetivo del estudio:
- Para reevaluar la evidencia de la selección natural que actúa sobre el gen ASPM.
- Para comparar el patrón de variación de ASPM con otros loci genéticos.
Principales métodos:
- Comparación empírica de la variación ASPM con un gran conjunto de datos de otros genes (loci).
- Análisis de los patrones de variación genética.
- Contraste con los análisis previos basados en simulación.
Principales resultados:
- El patrón de variación de ASPM, cuando se compara empíricamente con numerosos otros loci, no es inusual.
- Los datos empíricos no apoyan la hipótesis de una selección natural reciente en ASPM.
Conclusiones:
- La conclusión anterior de la selección natural en ASPM basada en simulaciones puede ser inexacta.
- Se necesitan más investigaciones para comprender la historia evolutiva de los genes asociados con el desarrollo del cerebro.
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