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¿Un solo origen del sistema nervioso central?

Maximilian J Telford¹

¹Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK. m.telford@ucl.ac.uk

|April 24, 2007

Resumen

Los patrones de expresión génica en embriones de cordados y anelidos muestran una similitud notable, lo que sugiere mecanismos antiguos de desarrollo del sistema nervioso heredados de un antepasado común. Esto indica que el sistema nervioso central es una antigua característica animal.

Área de la Ciencia:

Biología del desarrollo Biología del desarrollo.
La genómica comparada es una genómica comparada.
Biología evolutiva Biología evolutiva.

Sus antecedentes:

Investigando la expresión génica en embriones de cordados y anelidos.
Analizar los genes involucrados en el patrón del sistema nervioso.

Objetivo del estudio:

Investigar la conservación de los patrones de expresión génica implicados en el desarrollo del sistema nervioso en diferentes filos animales.
Para inferir el estado ancestral del patrón del sistema nervioso en el antepasado común bilateral.

Principales métodos:

Análisis comparativo de los perfiles de expresión génica.
Examen de los roles de los genes en el desarrollo del sistema nervioso embrionario en cordados y anelidos.

Principales resultados:

Los genes involucrados en el patrón del sistema nervioso exhiben perfiles de expresión y funciones conservadas tanto en cordados como en anelidos.
A pesar de las diferencias en la posición final del sistema nervioso central (dorsal en cordados, ventral en anelidos), los mecanismos genéticos subyacentes son muy similares.

Conclusiones:

Los mecanismos fundamentales para el patrón del sistema nervioso animal son antiguos y probablemente estuvieron presentes en el antepasado común bilateral.
El sistema nervioso central es una antigua característica animal, con su posicionamiento dorsal-ventral evolucionando independientemente en diferentes linajes.

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