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El control hormonal de la ingesta de alimentos
Anthony P Coll1, I Sadaf Farooqi, Stephen O'Rahilly
1Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge CB2 2XY, United Kingdom.
Cell
|April 24, 2007
Resumen
Las hormonas corporales como los péptidos y los esteroides regulan el apetito actuando en regiones clave del cerebro. Esta revisión sintetiza la evidencia sobre cómo estas hormonas de las células de grasa, el intestino y el páncreas afectan la ingesta de alimentos.
Área de la Ciencia:
- Endocrinología Endocrinología.
- La neurociencia es la neurociencia.
- El metabolismo es el metabolismo.
Sus antecedentes:
- La regulación del apetito es un proceso complejo influenciado por numerosas moléculas de señalización endógenas.
- Las hormonas juegan un papel crítico en la mediación del equilibrio energético y la ingesta de alimentos.
- Los sitios reguladores clave incluyen el hipotálamo, el tronco cerebral y el sistema nervioso autónomo.
Objetivo del estudio:
- Para sintetizar la evidencia científica reciente sobre el papel de las hormonas circulantes en el control del apetito.
- Para proporcionar una visión general de las hormonas que se originan en las células de grasa, el tracto gastrointestinal y el páncreas.
- Aclarar los mecanismos por los que estas hormonas influyen en la ingesta de alimentos.
Principales métodos:
- Revisión de la literatura de las publicaciones científicas recientes.
- Síntesis de la evidencia de estudios experimentales y observacionales.
- Análisis de las vías hormonales involucradas en la regulación del apetito.
Principales resultados:
- Los péptidos y esteroides circulantes son reguladores clave del apetito.
- Las hormonas del tejido adiposo, el tracto gastrointestinal y el páncreas afectan significativamente la ingesta de alimentos.
- Estas hormonas ejercen sus efectos a través de vías neuronales en el cerebro y el sistema nervioso autónomo.
Conclusiones:
- La señalización hormonal es fundamental para el control fisiológico del apetito.
- Comprender estas acciones hormonales es crucial para abordar los trastornos metabólicos.
- Investigaciones adicionales sobre estas vías pueden revelar objetivos terapéuticos para el control del apetito.
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