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Published on: January 10, 2015
Acciones sinápticas inhibidoras especializadas entre las neuronas piramidal neocorticales cercanas
Ming Ren1, Yumiko Yoshimura, Naoki Takada
1Department of Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan.
Science (New York, N.Y.)
|May 5, 2007
Resumen
Las neuronas excitadoras individuales en la corteza visual del ratón pueden desencadenar la inhibición en las células cercanas. Esto ocurre a través de la excitación de los terminales inhibidores de las interneuronas, independientemente de la activación de las interneuronas.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Los circuitos corticales son circuitos corticales.
- La transmisión sináptica es la transmisión sináptica.
Sus antecedentes:
- Las neuronas piramidales son las células excitatorias primarias en la corteza.
- Las interneuronas inhibidoras regulan la actividad cortical.
- Los mecanismos precisos por los cuales las neuronas excitadoras influyen en la inhibición no se comprenden completamente.
Objetivo del estudio:
- Para investigar cómo las neuronas excitatorias individuales en la corteza visual del ratón impactan los circuitos inhibidores locales.
- Para dilucidar los mecanismos sinápticos que median la inhibición evocada por la excitación.
Principales métodos:
- Electrofisiología in vivo en la corteza visual del ratón.
- Registro de las corrientes postsinápticas en las neuronas piramidal.
- Estimulación de las neuronas piramidal de una sola capa-2/3 .
Principales resultados:
- La actividad de una sola neurona piramidal evocaba con fiabilidad corrientes postsinápticas inhibidoras en las células piramidal vecinas.
- Este efecto fue mediado por la excitación axo-axónica de los terminales inhibidores de las interneuronas.
- La inhibición fue evocada independientemente de la activación somática de las interneuronas inhibidoras.
Conclusiones:
- Las neuronas excitadoras individuales pueden controlar directa y rápidamente la inhibición local.
- Esto proporciona un nuevo mecanismo para la regulación precisa de la actividad de la red cortical.
- Las neuronas excitadoras juegan un papel más directo en la configuración de la inhibición de lo que se pensaba anteriormente.
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