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One-step Negative Chromatographic Purification of Helicobacter pylori Neutrophil-activating Protein Overexpressed in Escherichia coli in Batch Mode
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One-step Negative Chromatographic Purification of Helicobacter pylori Neutrophil-activating Protein Overexpressed in Escherichia coli in Batch Mode

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Helicobacter pylori CagA se dirige a la quinasa PAR1/MARK para interrumpir la polaridad de las células epiteliales

Iraj Saadat1, Hideaki Higashi, Chikashi Obuse

  • 1Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Hokkaido University, Sapporo 060-0815, Japan.

Nature
|May 18, 2007
PubMed
Resumen

La proteína CagA de Helicobacter pylori interrumpe la polaridad de las células epiteliales gástricas al inhibir la PAR1 quinasa. Esta interacción promueve el alargamiento celular y contribuye al desarrollo de enfermedades gástricas.

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