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Updated: Jul 14, 2026

Comparing the Affinity of GTPase-binding Proteins using Competition Assays
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Comparing the Affinity of GTPase-binding Proteins using Competition Assays

Published on: October 8, 2015

GEF y GAP: elementos críticos en el control de las pequeñas proteínas G

Johannes L Bos1, Holger Rehmann, Alfred Wittinghofer

  • 1Department of Physiological Chemistry and Centre of Biomedical Genetics, UMC Utrecht Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. j.l.bos@umcutrecht.nl

Cell
|June 2, 2007
PubMed
Resumen

Los factores de intercambio de nucleótidos de guanina (GEF) y las proteínas activadoras de la GTPasa (GAP) controlan la señalización celular mediante la regulación de las pequeñas proteínas G. Estas proteínas están emergiendo como objetivos terapéuticos clave para enfermedades como el cáncer.

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