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La heredabilidad, el enlace y las asociaciones genéticas de las respuestas a las pruebas de la cinta de correr del
Erik Ingelsson1, Martin G Larson, Ramachandran S Vasan
1Framingham Study, Framingham, Mass, USA.
Circulation
|June 6, 2007
Resumen
Los factores genéticos influyen en la forma en que el cuerpo responde al ejercicio, afectando la presión arterial y la frecuencia cardíaca. Este estudio identifica la heredabilidad y sugiere vínculos genéticos para estas respuestas cardiovasculares cruciales.
Área de la Ciencia:
- Fisiología cardiovascular fisiología cardiovascular.
- Genética Humana Genética Humana.
- Ciencias del ejercicio Ciencia del ejercicio.
Sus antecedentes:
- La presión arterial (PA) y las respuestas de la frecuencia cardíaca durante la prueba de la cinta de correr son predictores establecidos de enfermedades cardiovasculares.
- Los fundamentos genéticos de estas respuestas hemodinámicas y cronotrópicas siguen siendo en gran parte inexplorados.
Objetivo del estudio:
- Investigar la heredabilidad y el vínculo genético de las respuestas hemodinámicas y cronotrópicas al ejercicio. pruebas de cinta de correr.
- Para identificar posibles asociaciones genéticas con cambios fisiológicos inducidos por el ejercicio.
Principales métodos:
- Evaluó la presión arterial sistólica, la presión arterial diastólica y la frecuencia cardíaca durante el ejercicio y la recuperación en 2982 participantes del estudio Framingham Offspring.
- Se estimó la heredabilidad utilizando métodos de componentes de varianza y se realizaron análisis cuantitativos de vinculación de rasgos.
- Asociaciones probadas con 235 polimorfismos de un solo nucleótido en 14 genes candidatos.
Principales resultados:
- Las estimaciones de heredabilidad para la frecuencia cardíaca durante el ejercicio y la recuperación fueron de 0,32 y 0,34, respectivamente.
- La heredabilidad para la presión arterial sistólica y diastólica por ejercicio fue de 0.25 y 0.26, disminuyendo a 0.16 y 0.13 durante la recuperación.
- Se encontró una relación sugerente para la presión arterial sistólica (locus 1q43-44) y la presión arterial diastólica (locus 4p15.3) durante la recuperación.
Conclusiones:
- Las respuestas hemodinámicas y cronotrópicas al ejercicio muestran una heredabilidad significativa.
- El enlace genético sugestivo indica regiones cromosómicas específicas que influyen en estas respuestas.
- Los futuros estudios de asociación de todo el genoma pueden descubrir nuevos conocimientos genéticos sobre la fisiología del ejercicio.
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An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes