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Regulación autocrina esencial por IL-21 en la generación de células T inflamatorias
Roza Nurieva1, Xuexian O Yang, Gustavo Martinez
1Department of Immunology, M. D. Anderson Cancer Center, Houston, Texas 77030, USA. rnurieva@mdanderson.org
Nature
|June 22, 2007
Resumen
La interleucina-21 (IL-21) es crucial para la diferenciación celular del T ayudante 17 (T(H) 17, actuando como un factor autocrino. Su deficiencia protege contra las enfermedades autoinmunes, destacando la IL-21 como un objetivo terapéutico.
Área de la Ciencia:
- Inmunología Inmunología.
- Biología celular Biología celular.
Sus antecedentes:
- Las células T ayudantes CD4+ se diferencian en subconjuntos como T(H) 1 y T(H) 2, cada uno con funciones únicas.
- Las células T ((H) 17 , un subconjunto distinto, median la inflamación del tejido y son inducidas por citocinas específicas y factores de transcripción.
Objetivo del estudio:
- Investigar el papel de la interleucina-21 (IL-21) en la diferenciación celular de T(H)17 y su potencial como objetivo terapéutico para enfermedades inflamatorias.
Principales métodos:
- Análisis de la expresión de citoquinas en células T(H) 17 de ratón.
- Investigando la inducción de IL-21 por IL-6 y su dependencia de STAT3 y ROR-gamma.
- Evaluación del efecto de la IL-21 en la diferenciación de T(H) 17 y la expresión de Foxp3.
- Evaluación del impacto de la deficiencia de IL-21 en la encefalomielitis autoinmune experimental.
Principales resultados:
- La IL-21 es altamente expresada por las células T(H) 17 del ratón e inducida por la IL-6 de una manera STAT3-dependiente.
- La IL-21 induce potentemente la diferenciación de T(H) 17 y suprime la expresión de Foxp3, requiriendo STAT3 y ROR-gamma.
- La deficiencia de IL-21 afecta la generación de células T(H) 17 y confiere protección contra la encefalomielitis autoinmune experimental.
Conclusiones:
- La IL-21 actúa como una citoquina autocrina suficiente y necesaria para la diferenciación de T{\displaystyle H}17.
- La IL-21 representa un objetivo terapéutico potencial para el manejo de enfermedades inflamatorias.
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