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Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
Published on: September 18, 2017
La cardiomiopatía diabética revisada fue revisada.
1Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA.
Circulation
|June 27, 2007
Resumen
La diabetes mellitus eleva significativamente el riesgo de insuficiencia cardíaca, incluso sin enfermedad arterial coronaria. Esta revisión explora los mecanismos emergentes detrás de la cardiomiopatía diabética y la disfunción cardíaca en la diabetes.
Área de la Ciencia:
- Cardiología Cardiología.
- Endocrinología Endocrinología.
- Fisiopatología Fisiopatología.
Sus antecedentes:
- La diabetes mellitus es un factor de riesgo conocido para la insuficiencia cardíaca.
- La cardiomiopatía diabética es cada vez más reconocida como una entidad clínica distinta.
- La patogénesis de la disfunción cardíaca en la diabetes es compleja y multifactorial.
Objetivo del estudio:
- Para revisar la comprensión actual de la disfunción cardíaca en la diabetes mellitus.
- Discutir los mecanismos emergentes que contribuyen a la cardiomiopatía diabética.
- Para sintetizar los hallazgos de estudios en humanos y modelos animales.
Principales métodos:
- Revisión de la literatura de estudios recientes sobre la diabetes y la disfunción cardíaca.
- Análisis de datos clínicos en humanos y hallazgos de modelos animales.
- Exploración de nuevas vías moleculares y celulares.
Principales resultados:
- La diabetes mellitus aumenta de forma independiente el riesgo de insuficiencia cardíaca.
- Varios factores contribuyen a la disfunción cardíaca en individuos diabéticos sin enfermedad arterial coronaria.
- Los mecanismos emergentes incluyen alteraciones metabólicas, inflamación y estrés oxidativo.
Conclusiones:
- La cardiomiopatía diabética es una complicación significativa de la diabetes mellitus.
- Una comprensión más profunda de la patogénesis es crucial para el desarrollo de terapias dirigidas.
- Se justifica una mayor investigación sobre nuevos mecanismos para prevenir y tratar la disfunción cardíaca en la diabetes.
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