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Inducción en el ojo compuesto en desarrollo de Drosophila: múltiples mecanismos restringen la inducción de R7 a una
D L Van Vactor1, R L Cagan, H Krämer
1Howard Hughes Medical Institute, Department of Biological Chemistry, UCLA School of Medicine 90024-1737.
Cell
|December 30, 1991
Resumen
Novia del ligando sieteless (jefe) y el control de los receptores sieteless (sev) Drosophila R7 desarrollo celular. La alteración de la expresión del jefe muestra que las células que expresan sev pueden adoptar el destino R7, incluso sin contacto celular R8, revelando nuevos conocimientos sobre la determinación del destino celular.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- La señalización celular de las células.
- La neurociencia es la neurociencia.
Sus antecedentes:
- El desarrollo de las células fotorreceptoras de Drosophila R7 depende de la señalización inductiva.
- La novia del ligando sevenless (jefe) y el receptor sevenless (sev) median esta interacción.
- Boss es específico de la célula R8, mientras que sev se expresa en múltiples tipos de células.
Objetivo del estudio:
- Para investigar el papel de la expresión espacial y temporal del jefe en la determinación del destino celular R7.
- Para comprender la capacidad de respuesta de las células que expresan sev a la señalización del jefe.
- Explorar cómo el compromiso temprano con el destino celular afecta la activación de la vía sev.
Principales métodos:
- Manipulación genética de la expresión génica del jefe en Drosophila.
- Análisis del destino de las células fotorreceptoras R7.
- Utilizando mutaciones en bruto y Nspl para estudiar el compromiso del destino celular.
Principales resultados:
- La alteración de la expresión del jefe indujo el destino de las células R7 en las células que expresan sev y no se ponen en contacto con R8.
- Las células precursoras R1-R6 que expresan sev y entran en contacto con R8 no respondieron al jefe.
- El compromiso temprano con el destino de R1-R6 bloqueó la activación de la vía sev.
Conclusiones:
- El control espacial y temporal del jefe es crucial para el destino de la célula R7.
- El contacto celular y el compromiso previo con el destino celular influyen en la capacidad de respuesta de la vía sev.
- Este estudio aclara los mecanismos clave en el desarrollo de los fotorreceptores de Drosophila.
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