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Preparation of Biopolymer Aerogels Using Green Solvents
Published on: July 4, 2016
Rápidamente in situ formando hidrogeles robustos y biodegradables mediante la combinación de estereocomplexión y
Christine Hiemstra1, Wei Zhou, Zhiyuan Zhong
1Department of Polymer Chemistry and Biomaterials, Faculty of Science and Technology, Institute for Biomedical Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Journal of the American Chemical Society
|July 25, 2007
Resumen
Este estudio combina la estereocomplexión y la fotopolimerización para crear hidrogeles robustos y de rápida formación. Estos hidrogeles avanzados ofrecen propiedades mecánicas mejoradas y degradación prolongada para aplicaciones biomédicas.
Área de la Ciencia:
- Ciencia de los Biomateriales Ciencia de los Biomateriales.
- Química de Polímeros La Química de Polímeros es la química de los polímeros.
- Ingeniería de materiales Ingeniería de materiales.
Sus antecedentes:
- La estereocomplexación de los copolímeros poli (etilenglicol) -poli (lactídeo) (PEG-PLA) forma hidrogeles.
- La formación in situ de hidrogeles es deseable para aplicaciones biomédicas.
- La combinación de métodos de enlace cruzado puede mejorar las propiedades del hidrogel.
Objetivo del estudio:
- Desarrollar rápidamente in situ formando hidrogeles robustos mediante la combinación de estereocomplexión y fotopolimerización.
- Para investigar el efecto de la posición de funcionalización del metacrilato en las propiedades del hidrogel.
- Evaluar las propiedades mecánicas y los perfiles de degradación de los hidrogeles combinados.
Principales métodos:
- Diseño y síntesis de PEG-PLLA y PEG-PDLA co-polímeros de bloque estrella funcionalizados con metacrilato.
- Formación rápida de hidrogeles estereocomplejos al mezclar soluciones de copolímero.
- Posterior fotopolimización de los hidrogeles estereocomplexados.
- Caracterización de los módulos de almacenamiento de hidrogel, comportamiento de hinchazón y degradación.
Principales resultados:
- La formación rápida de hidrogel (1-2 min) se logra a una concentración de polímero del 12,5-17.5% (p/v).
- La estereocomplexación combinada y la fotopolimerización aumentaron significativamente los módulos de almacenamiento en comparación con los métodos individuales.
- El módulo de almacenamiento aumentó linealmente con el tiempo de estereocomplexión, lo que indica una sinergia.
- La fotopolimerización es efectiva en concentraciones muy bajas de iniciador (0,003 wt %).
- Los hidrogeles combinados exhibieron tiempos de degradación prolongados (3-16 + semanas) frente a los hidrogeles solo fotopolimerizados (1,5 semanas).
Conclusiones:
- La combinación de estereocomplexión y fotopolimerización es una nueva estrategia para crear rápidamente in situ formando, hidrogeles robustos.
- La posición de la funcionalización del metacrilato influye en las tasas de degradación.
- Estos hidrogeles avanzados son prometedores para aplicaciones que requieren formación rápida, resistencia mecánica y degradación controlada.
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