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Patogénesis y características clínicas de la psoriasis
Christopher Em Griffiths1, Jonathan Nwn Barker2
1Dermatology Centre, Hope Hospital, University of Manchester, Manchester M6 8HD, UK.
Lancet (London, England)
|July 31, 2007
Resumen
La psoriasis es una enfermedad de la piel mediada por el sistema inmunológico que involucra queratinocitos epidérmicos, células T y el factor de necrosis tumoral alfa. Comprender su patogénesis y comorbilidades como la artritis psoriásica es clave para desarrollar nuevos tratamientos.
Área de la Ciencia:
- La inmunodermatología.
- Genética La genética.
- Fisiopatología Fisiopatología.
Sus antecedentes:
- La psoriasis, una enfermedad papulosquamous, ahora se reconoce como un trastorno inmune mediado común.
- El factor de necrosis tumoral alfa, las células dendríticas y las células T son los principales contribuyentes a la patogénesis de la psoriasis.
- La psoriasis de inicio temprano está influenciada por HLA-Cw6 y factores ambientales como las infecciones por estreptococos.
Objetivo del estudio:
- Para revisar la patogénesis de la psoriasis.
- Para discutir los determinantes genéticos y ambientales de la psoriasis.
- Para explorar las comorbilidades asociadas con la psoriasis.
Principales métodos:
- Revisión de la literatura actual sobre la patogénesis de la psoriasis.
- Análisis de los loci de susceptibilidad genética para la psoriasis.
- Examen de los fenotipos clínicos y las comorbilidades de la psoriasis.
Principales resultados:
- La psoriasis implica vías inmunológicas complejas y factores genéticos.
- El transporte e infecciones de HLA-Cw6 son significativos en la enfermedad de inicio temprano.
- La psoriasis en placas crónicas (psoriasis vulgaris) es la forma más común.
- Las comorbilidades incluyen deterioro de la calidad de vida, depresión, enfermedades cardiovasculares y artritis psoriásica.
Conclusiones:
- Una comprensión completa de los patomecanismos de la psoriasis está avanzando las estrategias de tratamiento.
- La psoriasis es una condición multifacética mediada por el sistema inmunológico con comorbilidades significativas.
- Una mayor investigación sobre los mecanismos subyacentes impulsará la innovación terapéutica.
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