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La progresión del atheroma del arco aórtico y los eventos vasculares recurrentes en pacientes con accidente
Souvik Sen1, Alan Hinderliter, Pranab K Sen
1Department of Neurology, University of North Carolina, Chapel Hill, USA. SenS@neurology.unc.edu
Circulation
|August 9, 2007
Resumen
La progresión del atheroma del arco aórtico en pacientes con accidente cerebrovascular o AIT está relacionada con un aumento de los eventos vasculares. Este hallazgo pone de relieve la importancia de monitorear el atheroma en estos individuos de alto riesgo.
Área de la Ciencia:
- Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
- Neurología Neurología.
- Biología Vascular Biología Vascular
Sus antecedentes:
- El atheroma del arco aórtico (AA) es un factor de riesgo conocido para eventos cerebrovasculares.
- La asociación entre la progresión del atheroma AA y los sucesos vasculares subsiguientes en pacientes con accidente cerebrovascular / AIT sigue sin estar clara.
Objetivo del estudio:
- Investigar si la progresión del ateroma AA está asociada con eventos vasculares recurrentes en pacientes que han sufrido un accidente cerebrovascular o un ataque isquémico transitorio (AIT).
Principales métodos:
- Se evaluaron 167 pacientes con accidente cerebrovascular / AIT y ateroma AA basal en el ecocardiograma transesofágico (TEE).
- 117 pacientes se sometieron a un seguimiento de 12 meses de TEE.
- Se evaluó la progresión del ateroma AA y se realizó un seguimiento de los pacientes para detectar eventos vasculares.
Principales resultados:
- La progresión del atheroma AA se observó en el 28% de los pacientes durante 12 meses.
- La progresión se asoció con niveles más altos de homocisteína y neutrófilos.
- Los pacientes con progresión de atheroma AA tenían una tasa significativamente mayor de eventos vasculares compuestos (HR 5,8, P = 0,0002).
Conclusiones:
- La progresión del atheroma del arco aórtico se asocia con eventos vasculares recurrentes en pacientes con antecedentes de accidente cerebrovascular o AIT.
- Este estudio preliminar sugiere que el monitoreo de la progresión del atheroma AA puede ser importante para la estratificación del riesgo en pacientes con accidente cerebrovascular / TIA.
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